The study was carried out to determine if family and school climate predict children’s vulnerability to trafficking in Anambra State. In pursuance of the above objective, six research questions and six hypotheses guided the study. The instrument used for data collection was a researcher designed questionnaire titled “Students’ Vulnerability toTrafficking Questionnaire (SVTQ)”. Copies of the instrument were given to experts in the Faculty of Education, University of Nigeria, Nsukka, to validate and their corrections were effected. To test the reliability of the instrument, copies of the instrument were given to 50 Senior SecondarySchool students and the result was analyzed using Cronbach AlphaStatistics. No of respondents used as sample were 1164. The sampling technique used was multistage sampling design. Stratified random sampling was used to select the three education zones while simple random sampling with replacement was used to select the four schools used in each education zone. Purposive sampling method was used in selecting 100 children used in each school. The data were analyzed usingPearson Product Moment Correlation for the research questions andMultiple Regression for the hypotheses. The findings showed that family and school climate are predictors of children’s vulnerability to trafficking.Family socio-economic status, family size, family structure, family climate, teacher-student relationship and student-student relationship significantly predict children’s vulnerability to trafficking. Based on the findings, implications were highlighted and recommendations were made among them is creating awareness of the modern day slavery-trafficking.